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Massive Bioinformatics

Who are we?

At Massive Bioinformatics, we are a team of dedicated scientists, software engineers, and bioinformatics experts who are passionate about utilizing the power of bioinformatics and biotechnology to improve the quality of life on earth. We specialize in providing pioneering, high-value-added products and services that leverage biotechnology and information systems to advance health, science, and technology.

Our team combines their expertise to offer a range of services, software, and devices that include next-generation sequencing (NGS), COVID-19 genome analysis, phylogeny and transmission analysis, and whole genome construction from metagenomic data and many more.  We provide more accurate results and superior insights with our long-read technology and analysis softwares.

We take pride in our commitment to excellence and are dedicated to providing the best possible solutions for our clients. Contact us today to learn how we can help you advance your research and innovation in biotechnology.

Holistic Approach

Our team of software engineers and bioinformatics experts create sophisticated information systems that provide actionable insights and analysis.

Innovative Solutions

We leverage the latest biotechnology to develop groundbreaking solutions that solve real-world problems. Partnerships bring us together.

Privacy

We understand that genetic information is highly sensitive and can reveal personal and intimate details about individuals. Therefore, we prioritize the privacy and security of genetic data throughout our analysis process. We follow all relevant regulations and standards, including the GDPR and KVKK.

Oxford Nanopore Technologies

Molzym

Nonacus

Bento

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Oxford Nanopore

Molzym

Nonacus

Bento

Discover all our services

At Massive Bioinformatics, we provide comprehensive bioinformatics solutions to support your scientific research and data analysis needs. From genetic data analysis to bioinformatics consulting, we offer a world of knowledge you want to discover. We invite you to explore our tailored solutions and unlock your research potential!

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Antimicrobial Resistance

Antimicrobial resistance (AMR) is a critical global health issue addressed through metagenomics, which examines resistomes in diverse microbial environments. Using Oxford Nanopore’s long reads, antibiotic resistance genes are identified in raw data through shotgun metagenomic and whole genome sequencing, leveraging the Comprehensive Antibiotic Resistance Database (CARD).

16S – 23S Metagenomics

Metagenomics enables the assessment of microbial diversity and quantities within samples. While 16S rRNA gene identification at ~1500 bp is common, many modern sequencing methods use only a ~450 bp fragment, leading to inaccuracies. Oxford Nanopore’s long reading technology enhances species identification by reading the full 1500 bp gene, advancing the field. Metagenomic analyses offer extensive options for detailed exploration of diverse sample types or components

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WHOLE GENOME SEQUENCING

Whole genome analysis involves a thorough study of an organism’s entire genome and its functional genes. This method detects variants – differences from the reference genome – along with antimicrobial resistance genes, secondary metabolite genes, and virulence genes in the annotated genome. It also includes tools like alignment images, circular genome depictions, genome comparison with close subspecies, polymorphism tables.

Amplicon Sequencing

Experience our Amplicon Sequencing Service—a tailored genetic analysis solution crafted to reveal precise insights from DNA or RNA samples. Through targeted amplification and sequencing of specific regions, we deliver focused, high-resolution data ideal for identifying mutations, uncovering genetic diversity, and tracing variations. Our state-of-the-art technology ensures precise outcomes, even with limited genetic material, enabling swift and cost-effective decision-making. Whether in medical advances or environmental exploration, our Amplicon Sequencing Service paves the way for efficient and impactful genetic analysis.

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RNA SEQUENCING

We offer comprehensive RNA-Seq analyses,  differential gene expression (DEGs), fusion gene discovery, and variant identification such as  SNVs and Indels. These evaluations are conducted by skilled bioinformaticians utilizing cutting-edge technology and top-tier algorithms. Our bioinformatics solution facilitates both a comprehensive overview and detailed exploration of your RNA data, highlighting expression patterns through heatmap and Principal Component Analysis (PCA). Addi tionally, enrichment analyses employing databases like KEGG, GO, DO, Reactome, and WikiPathways yield valuable insights into the functional implications of your RNA data.

COVID19 Genome Analysis

With our customized pipeline for detection of SARS-CoV-2 based on Oxford Nanopore sequencing technology which utilizes the benefits of long reads. Our service aligns the reads to SARS-CoV-2 reference genome, calls variants, and generates a consensus genome sequence. It then determines lineage, clade and phylogenetic tree information of the sample using Pangolin and NextClade. All the information with its data and QC metric files gets summarized in one extensive html report for easy viewing.

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Next Generation Sequencing

Oxford Nanopore Technologies

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ANALYSE

Featured in scientific publication

includes more than 2,000 patents and applications

amount of data that can be received at once with 48 flowcells

Gut Microbiota Plays a Role in Brain Growth

Home to trillions of bacteria and thousands of species, the gut microbiota can influence human physiology in a variety of ways. As humans, our gut microbiota begins to form during our mothers' pregnancy. Together, the genome of all these microorganisms represents the...

The 10 Most Important Bioinformatics Breakthroughs of the Past Year!

In 2023, bioinformatics discoveries accelerated progress in the life sciences. These groundbreaking discoveries have provided insights into the complex workings of biological systems, processes and disease states. From discovering new diagnostic markers to mapping the...

Databases that we use in pipelines

Clinical Genomic Database (CGD) Clinical Genomic Database (CGD), is a manually curated database of conditions with known genetic causes, focusing on medically necessary genetic data with available interventions. All conditions with identified genetic causes are...

External Links for Variants

External links can be used as valuable tools to pass through between different useful sources. Different sources links are utilized as external links in this application. These are: VarSome [1] Franklin [2] ClinVar [3] dbSNP [4] HGNC [5]...

Compatible sequencers with Massive Analyser

Sequencing machines are scientific devices that aid in the automation of the DNA sequencing process. In sequencing technology, there are various types of sequencing devices. Each device has its own DNA sequencing methods. Our system currently supports two sequencing...

Compatible Kits with Massive Analyser

Our system supports the kits listed below: 1. Twist 1.1. Twist Comprehensive Exome Panel [1] Exome sequencing has become a widely used practice in clinics and diagnostics. To meet this need, the content of the Twist Human Nucleus Exome has been designed to cover...

Family Trio Analysis

NGS technology of family trio analysis offers a powerful approach for identifying causal variations for inherited diseases. Trio analysis can identify variants inherited from the parents. For example, if a variant appears only in the mother, and the father and child...

ACMG Rules

In 2013, ACMG group members came together to develop a recommendation for using standard terminology for classifying variants using applicable rules. Different rules/criteria are assigned to classify variants bearing the said rule's feature. As mentioned below, each...

Dictionary

Scientific Dictionary Scientific Dictionary A B C D E F G H I M Q S T A Adapter Adapter is an oligonucleotide sequence that is attached to the ends of the DNA sequence by ligation or rapid chemistry. It carries a motor protein that plays a role in separating the...

Dictionary of Key Concepts

    TERM DEFINITION Adapter Adapter is an oligonucleotide sequence that is attached to the ends of the DNA sequence by ligation or rapid chemistry. It carries a motor protein that plays a role in separating the strands of the DNA molecule, aiding the strand...

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From customized bioinformatics analysis and interpretation to our innovative software tools, we have everything you need to accelerate your research and make groundbreaking discoveries.

Whether you’re an academic researcher, a pharmaceutical company, or a healthcare provider, we invite you to explore our full range of services and products today. Contact us to schedule a meeting with one of our experts and discover how we can help you achieve your research goals. Together, we can make a difference.